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New Insights on HIV virus revealed by Abberior STED-FCS

2020-04-22

Using Abberior STED-FCS, a team from four European countries, comprising Christian Eggeling (Leibniz IPHT & Friedrich Schiller University Jena) and Delphine Muriaux (Montpellier Infectious Disease Research Institute) discovered the existence and composition of a lipid-based platform for HIV virus assembly.

These results provide novel molecular insights on HIV virus assembly and are a starting point for the development of new antiviral drugs.

 

Citation: C. Favard, J. Chojnack, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling and D. Muriaux, "HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly", Science Advances, 02 Oct 2019: Vol. 5, no. 10.